I believe that the Apple USB driver is not reporting the ADC/DAC latency. So the reported USB latency is not accurate; the actual latency is almost certainly higher.

The MHLink driver also has somewhat higher safety offsets to cope with the scheduling jitter for sending Ethernet packets.

The USB transport is 24bit, the MHLink transport is 32 bit; whether or not that makes a difference is debatable.

The MHLink transport supports a far higher channel count, and works properly at 2x and 4x rates when MIO Console is active, whereas the USB transport may encounter errors at > 1x rates when MIO Console is active.

These differences are all with the Apple USB driver. When we provide a custom driver for USB the USB limitations should be reduced. But USB will not provide as many total channels as MHLink does.